Mehreen Pirzadaa debuted in Tamil in Nenjil Thunivirundhal starring with Sundeep Kishan, Vikranth, Soori, Appukutty etc., The movie ended up as a flop and it has been announced that she will be making comeback in Tamil cinema with Dhanush's next untitled project. This yet to be titled film will have Sneha in an important role for  which Mehreen Pirzadaa is the leading lady. The latest news is that Mehreen is learning Tamil on the sets of her current project, Gopichand’s Chanakya, a Telugu spy thriller.

The movie Chanakya is directed by Thiru who has directed films in Tamil like Mr. Chandramouli, Naan Sigappu Manithan, Samar and Theeradha Vilayattu Pillai. Apparently Mehreen Pirzadaa is learning 4-5 Tamil words per day from the director for Dhanush's film, through which the actor's determination could be seen. She has also played the character of Swathi Mahendran in the movie NOTA.